Open Access
Article
A single clone of T cells may identify 'self' from 'non-self' through different recognition mechanisms
Yan-Ming Liu1,Jing Luo1,Di Chen1
1
Tianjin University of Tradional Chinese Medicine, Tianjin, 300193, China. lym2163@hotmail.com
DOI: 10.2741/2743 Volume 13 Issue 3, pp.1062-1063
Published: 01 January 2008
(This article belongs to the Special Issue TGFbeta,BMP receptor signaling)
Abstract

T cell antigen recognition is a special process. The complicated bindings between T cell receptor (TCR) or co-receptor (CD4 or CD8) and antigen peptide-major histocompatibility complex (pMHC) molecules have specific physiological significance. Recent reports show that different recognition models do exist in recognizing pMHCs by a single T cell. These different recognition mechanisms allow a single T cell to identify 'self' from 'non-self' and result in different biological consequence.

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Yan-Ming Liu, Jing Luo, Di Chen. A single clone of T cells may identify 'self' from 'non-self' through different recognition mechanisms. Frontiers in Bioscience-Landmark. 2008. 13(3); 1062-1063.