Open Access
Article
New insights into sperm-zona pellucida interaction: involvement of sperm lipid rafts
Nongnuj Tanphaichitr1,Euridice Carmona1,Maroun Bou Khalil1,Hongbin Xu1,Trish Berger1,George L Gerton1
1
Hormones/Growth/Development, Ottawa Health Research Institute and Department of Biochemistry/Microbiology/Immunology, University of Ottawa, Ottawa, Ontario, Canada. ntanphaichitr@ohri.ca
DOI: 10.2741/2186 Volume 12 Issue 5, pp.1748-1766
Published: 01 January 2007
(This article belongs to the Special Issue Sperm biology, from basic to clinic)
Abstract

Sperm-zona pellucida (ZP) binding is the first step of gamete interaction. This binding occurs in two sequential steps, starting with the primary binding of acrosome-intact sperm to the ZP followed by the secondary ZP binding of acrosome reacting/reacted sperm. While there are only a few ZP sulfoglycoproteins involved in these binding events, a large number of sperm surface molecules have been shown to possess ZP affinity. In this review, we have given explanations to the existence of these many ZP binding molecules. We have also summarized their origin and the mechanisms of how they are targeted to the sperm surface and acrosome. Recently, we have shown that sperm lipid rafts have affinity for the ZP. A number of ZP binding molecules are also present in sperm lipid rafts. In this review, we have provided an argument that sperm lipid rafts may be the platforms on the sperm surface for ZP interaction.

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Nongnuj Tanphaichitr, Euridice Carmona, Maroun Bou Khalil, Hongbin Xu, Trish Berger, George L Gerton. New insights into sperm-zona pellucida interaction: involvement of sperm lipid rafts. Frontiers in Bioscience-Landmark. 2007. 12(5); 1748-1766.