Open Access
Oxidative stress and apoptosis: a new treatment paradigm in cancer
Ryan H Engel1,Andrew M Evens1
Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, The Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA
DOI: 10.2741/1798 Volume 11 Issue 1, pp.300-312
Published: 01 January 2006
(This article belongs to the Special Issue New modalities in cancer therapy)

Redox regulation has been shown to be an important component of malignant cell survival. Tipping the cellular redox balance through pharmacologic regulation in favor of increasing intracellular reactive oxygen species (ROS) and/or depleting protective reducing metabolites (such as glutathione and nicotinamide adenine dinucleotide phosphate) may lead to oxidative stress and resultant induction of apoptosis for the treatment of cancer. We review the biology and importance of ROS with regard to malignant and normal cells. Moreover, we discuss pre-clinical and clinical data regarding novel therapeutic agents that modulate the cellular redox system including buthionine sulfoximine, ascorbic acid, arsenic trioxide, imexon, and motexafin gadolinium as single-agents and in combination. Continued research is needed to better understand the mechanisms and specific apoptotic pathways involved in ROS-induced cell death, as well as, to determine the most rationale and effective combination of redox-active agents.

Share and Cite
Ryan H Engel, Andrew M Evens. Oxidative stress and apoptosis: a new treatment paradigm in cancer. Frontiers in Bioscience-Landmark. 2006. 11(1); 300-312.