Navigation
Open Access
Article
Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis
Paul C Chin1,Santosh R D'Mello1
1
The Molecular and Cell Biology Department, FO 3.1, The University of Texas at Dallas, P.O. Box 830688, Richardson, Texas 75083-0688, USA
DOI: 10.2741/1551 Volume 10 Issue 1, pp.552-568
Published: 01 January 2005
(This article belongs to the Special Issue Current status in alzheimers research)
Abstract

Increasing evidence implicates aberrant apoptosis as a fundamental cause of neurodegenerative diseases. Thus elucidating the underlying causes of neuronal programmed cell death may foster the development of therapeutic interventions. Research in the last 15 years provided a solid foundation for understanding molecular mechanisms of neuronal apoptosis. This review discusses the major molecules and signaling pathways leading to neuronal survival or apoptosis with emphasis on several small molecule inhibitors that target neuronal survival with the hope of impeding the detrimental effects of neurodegenerative diseases.

Share and Cite
Paul C Chin, Santosh R D'Mello. Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis. Frontiers in Bioscience-Landmark. 2005. 10(1); 552-568.