Open Access
Transverse Myelitis: pathogenesis, diagnosis and treatment
Chitra Krishnan1,Adam I Kaplin1,Deepa M Deshpande1,Carlos A Pardo1,Douglas A Kerr1
Department of Neurology, Johns Hopkins Transverse Myelitis Center, 600 N. Wolfe Street Pathology 627C, Baltimore MD 21287-6965, USA.
DOI: 10.2741/1351 Volume 9 Issue 2, pp.1483-1499
Published: 01 May 2004
(This article belongs to the Special Issue Inflammatory disorders of the nervous system)

Transverse Myelitis (TM) is a clinical syndrome in which an immune-mediated process causes neural injury to the spinal cord, resulting in varying degrees of weakness, sensory alterations and autonomic dysfunction. TM may exist as part of a multi-focal CNS disease (e.g. MS), multi-systemic disease (e.g. systemic lupus erythematosus), or as an isolated, idiopathic entity. In this article, we will summarize recent classification and diagnostic schemes (1), which provide a framework for the acute management of patients with TM. Additionally, we will review current concepts on the natural history, immunopathogenesis and treatment strategies for patients with TM.

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Chitra Krishnan, Adam I Kaplin, Deepa M Deshpande, Carlos A Pardo, Douglas A Kerr. Transverse Myelitis: pathogenesis, diagnosis and treatment. Frontiers in Bioscience-Landmark. 2004. 9(2); 1483-1499.