Open Access
The role of oxidative damage in mitochondria during aging: a review
Hai Huang1,Kenneth G Manton1
Center for Demographic Studies, Duke University, 2117 Campus Drive Box 90408, Durham, NC 27708, USA.
DOI: 10.2741/1298 Volume 9 Issue 2, pp.1100-1117
Published: 01 May 2004
(This article belongs to the Special Issue Bio-demographic effects of genome-proteome interactions)

Aging is a complex process (or series of processes). Recent evidence suggests that several of its most important mechanisms are linked by means of cellular damage caused by reactive oxygen species (ROS). Oxidative damage may be a major factor in the loss of physiological functions that occur in degenerative diseases and aging. This is because, in aerobic organisms, the mitochondrial electron transport chain plays an important role in energy production and is a significant source of ROS that damage DNA, RNA, and proteins in cells. While oxidative events in other cell organelles are likely to contribute to the pathobiology of aging, this review highlights alterations in mitochondrial function that, due to accumulated oxidative damage, occur with age.

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Hai Huang, Kenneth G Manton. The role of oxidative damage in mitochondria during aging: a review. Frontiers in Bioscience-Landmark. 2004. 9(2); 1100-1117.