Open Access
Article
Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation
Rukiye-Nazan E Dogan1,William J Karpus1
1
Department of Pathology, Interdepartmental Immunobiology Center, Robert H. Lurie Comprehensive Cancer Center, and the Institute for Neuroscience, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
DOI: 10.2741/1284 Volume 9 Issue 2, pp.1500-1505
Published: 01 May 2004
(This article belongs to the Special Issue Inflammatory disorders of the nervous system)
Abstract

This article focuses on the distinct role of chemokines and chemokine receptors during CNS inflammation in experimental autoimmune encephalomyelitis (EAE) as an animal model for multiple sclerosis (MS). We review the evidence that chemokines and chemokine receptors have an intrinsic role in regulating and amplifying the inflammatory reactions in EAE or MS leading to disease outcome. A variety of studies examining temporal chemokine expression patterns, using chemokine and chemokine receptor knockout mice as well as administering passive anti-chemokine antibodies indicates that these molecules are critical regulatory components for leukocyte recruitment and/or leukocyte retention in the CNS. Therefore, chemokine and chemokine receptor expression is tightly interrelated to composition of inflammatory cells in CNS lesions and the onset of clinical diseases and provide viable targets for therapeutic intervention.

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Rukiye-Nazan E Dogan, William J Karpus. Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation. Frontiers in Bioscience-Landmark. 2004. 9(2); 1500-1505.