Open Access
B cells in multiple sclerosis
Mark P Burgoon1,Donald H Gilden1,Gregory P Owens1
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
DOI: 10.2741/1278 Volume 9 Issue 1, pp.786-796
Published: 01 January 2004
(This article belongs to the Special Issue Inflammatory disorders of the nervous system)

The most common laboratory abnormality in multiple sclerosis (MS) is an increased amount of cerebrospinal fluid IgG and the presence of oligoclonal bands. Despite studies of the humoral response that suggest the involvement of an infectious agent or autoantigen in disease, the major targets of the oligoclonal response are still unknown. Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment.

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Mark P Burgoon, Donald H Gilden, Gregory P Owens. B cells in multiple sclerosis. Frontiers in Bioscience-Landmark. 2004. 9(1); 786-796.