Open Access
Sepsis associated encephalopathy (SAE): a review
Rebecca Green1,L Keith Scott1,Alireza Minagar1,Steven Conrad1
Critical Care Medicine, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71130, USA
DOI: 10.2741/1250 Volume 9 Issue 2, pp.1637-1641
Published: 01 May 2004
(This article belongs to the Special Issue Inflammatory disorders of the nervous system)

Sepsis associated encephalopathy (SAE) is a poorly understood condition that is associated with severe sepsis and appears to have a negative influence on survival. The incidence of encephalopathy secondary to sepsis is unknown. Amino acid derangements, blood-brain barrier disruption, abnormal neurotransmitters, and direct CNS effect are possible causes of septic encephalopathy. Research has not defined the pathogenesis of SAE.

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Rebecca Green, L Keith Scott, Alireza Minagar, Steven Conrad. Sepsis associated encephalopathy (SAE): a review. Frontiers in Bioscience-Landmark. 2004. 9(2); 1637-1641.