Open Access
Article
Regulation of CDC14: pathways and checkpoints of mitotic exit
Joshua Bembenek1,Hongtao Yu1
1
Department of Pharmacology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9041, USA
DOI: 10.2741/1128 Volume 8 Issue 4, pp.1275-1287
Published: 01 September 2003
(This article belongs to the Special Issue Cell cycle checkpoint control)
Abstract

Progression of the mitotic cell cycle is driven by fluctuations of the cyclin-dependent kinase (Cdk) activities. Entry into mitosis is promoted by the elevated activity of Cdk1 associated with B-type cyclins. Conversely, exit from mitosis requires the inactivation of Cdk1 and the dephosphorylation of at least a subset of Cdk1 substrates. The Cdc14 family of phosphatases antagonizes the action of Cdk1, and is thus a major player in controlling the mitotic exit. We review recent discoveries in several model systems that have shed light on the function of Cdc14 and propose a general framework within which Cdc14 plays conserved roles in regulating the exit from mitosis and cytokinesis.

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Joshua Bembenek, Hongtao Yu. Regulation of CDC14: pathways and checkpoints of mitotic exit. Frontiers in Bioscience-Landmark. 2003. 8(4); 1275-1287.