Open Access
BRCA proteins and DNA damage checkpoints
Zhenkun Lou1,Junjie Chen1
Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
DOI: 10.2741/1127 Volume 8 Issue 6, pp.718-721
Published: 01 May 2003
(This article belongs to the Special Issue Cell cycle checkpoint control)

BRCA1 and BRCA2 are frequently mutated in breast cancer patients, responsible for the majority cases of familial breast cancer. Through genetic and biochemical analysis, the function of BRCA1 and BRCA2 is emerging. This review examines recent progresses in understanding the roles of BRCA proteins in DNA damage checkpoint control and how they are regulated in response to DNA damage

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Zhenkun Lou, Junjie Chen. BRCA proteins and DNA damage checkpoints. Frontiers in Bioscience-Landmark. 2003. 8(6); 718-721.