Open Access
Role of complement in the pathogenesis of SIV infection
Doris Freissmuth1,Manfred P Dierich1,Heribert Stoiber1
Institute of Hygiene Social Medicine and Ludwig-Boltzmann-Institute for AIDS Research, University Innsbruck, Austria
DOI: 10.2741/1124 Volume 8 Issue 6, pp.733-739
Published: 01 May 2003
(This article belongs to the Special Issue Natural lentivirus infection of non-human primates)

Lentiviruses have adapted several strategies to avoid complement-mediated lysis. Thus, interaction of HIV or SIVmac with complement proteins and the subsequent binding to complement receptor (CR) positive cells, leads to significant enhancement of infection. In addition, the trapping of viral antigens and intact infectious viruses on follicular dendritic cells in the lymphatic tissue is, in the case of HIV, strongly dependent on complement. In contrast, natural hosts of primate lentiviruses such as African green monkeys, Sooty mangabeys or Chimpanzees are resistant to the development of clinical AIDS despite persistent replication of SIV. In the present review interactions of lentiviruses with complement in different primate species and the possible consequences of such interactions for the progression to AIDS in different hosts are discussed.

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Doris Freissmuth, Manfred P Dierich, Heribert Stoiber. Role of complement in the pathogenesis of SIV infection. Frontiers in Bioscience-Landmark. 2003. 8(6); 733-739.