Open Access
Article
PYK2 and FAK in osteoclasts
Wen-Cheng Xiong1,Xu Feng1
1
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
DOI: 10.2741/1117 Volume 8 Issue 4, pp.1219-1226
Published: 01 September 2003
(This article belongs to the Special Issue FAK family kinases in disease)
Abstract

Integrin alpha(v)beta3 plays a pivotal role in osteoclastic bone resoprtion by mediating both osteoclast attachments on bone matrix and cytoskeleton reorganization. The focal adhesion kinase (FAK) family kinases including FAK and proline-rich tyrosine kinase 2 (PYK2) are major tyrosine kinases activated by integrin engagement. In osteoclasts, although FAK is expressed, PYK2 appears to be the predominant mediator of integrin alpha(v)beta3 signaling events that influence osteoclast physiology and pathology. Recent progress in the understanding of the role of PYK2/FAK kinases in the regulation of osteoclastic actin cytoskeletal organization, cell migration, and bone resorption will be discussed in this review.

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Wen-Cheng Xiong, Xu Feng. PYK2 and FAK in osteoclasts. Frontiers in Bioscience-Landmark. 2003. 8(4); 1219-1226.