Open Access
Role of vasoactive mediators in the pathogenesis of Chagas' disease
Shankar Mukherjee1,Huan Huang1,Louis M Weiss1,Sylvia Costa1,Julio Scharfstein1,Herbert B Tanowitz1
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
DOI: 10.2741/1103 Volume 8 Issue 5, pp.410-419
Published: 01 May 2003
(This article belongs to the Special Issue Infectious diseases of the myocardium)

This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoactive peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.

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Shankar Mukherjee, Huan Huang, Louis M Weiss, Sylvia Costa, Julio Scharfstein, Herbert B Tanowitz. Role of vasoactive mediators in the pathogenesis of Chagas' disease. Frontiers in Bioscience-Landmark. 2003. 8(5); 410-419.