Open Access
Early onset parkinsonism
Oscar S Gershanik1
Sección Enfermedades Extrapiramidales, Centro Neurológico-Hospital Francés & Laboratory of Experimental Parkinsonism, Instituto de Investigaciones Farmacológicas, ININFA-CONICET, Buenos Aires, Argentina.
DOI: 10.2741/1100 Volume 8 Issue 6, pp.568-578
Published: 01 May 2003
(This article belongs to the Special Issue Parkinson disease)

Early-onset parkinsonism refers to those patients with onset of a parkinsonian syndrome before age 40. These cases can be further subdivided into Young-onset (between ages 40 and 21) and Juvenile-onset (below age 21). In this review we will focus on the peculiar clinical features that distinguish these cases from classic late-onset parkinsonism, their characteristic response to medication, and their heterogeneous pathogenesis, including recent findings in the field of genetics that would suggest that a significant number of these patients are the result of genetic mutations.

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Oscar S Gershanik. Early onset parkinsonism. Frontiers in Bioscience-Landmark. 2003. 8(6); 568-578.