Open Access
Article
Snares for GLUT4--mechanisms directing vesicular trafficking of GLUT4
Julian Grusovin1,S Lance Macaulay1
1
CSIRO Health Science and Nutrition, 343 Royal Parade, Parkville, Victoria, Australia 3052
DOI: 10.2741/1052 Volume 8 Issue 4, pp.620-641
Published: 01 May 2003
(This article belongs to the Special Issue Insulin regulation of glucose transport)
Abstract

Fusion of GLUT4 vesicles with the plasma membrane is a key terminal step in insulin-regulated glucose transport. This fusion event is mediated by SNARE proteins, syntaxin 4, SNAP23 and VAMP2, through a process regulated by accessory proteins whose roles are still unclear. Munc18c is a key regulatory protein of syntaxin, and possibly of whole-SNARE complex cycling. Rab GTPases, through interactions with tethering molecules and SNAREs, provide targeting specificity in the GLUT4 secretory pathway. We review here insulin-mediated signaling of glucose transport, and particularly the role played by SNAREs and their accessory proteins.

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Julian Grusovin, S Lance Macaulay. Snares for GLUT4--mechanisms directing vesicular trafficking of GLUT4. Frontiers in Bioscience-Landmark. 2003. 8(4); 620-641.