Open Access
Article
Chromatin dynamics and DNA repair
Tsuyoshi Ikura1,Vasily V Ogryzko1
1
Research Institute for Radiation Biology and Medicine, Department of experimental oncology, Hiroshima University, Hiroshima 734-8553, Japan
DOI: 10.2741/1013 Volume 8 Issue 6, pp.149-155
Published: 01 January 2003
(This article belongs to the Special Issue DNA metabolism within a nucleosomal context)
Abstract

Packing of the eukaryotic genome into chromatin poses an accessibility problem for the DNA repair machinery. Chromatin structure has to be changed for the repair to occur, and we are beginning to discover how different chromatin modifying mechanisms facilitate DNA repair in the chromatin context. On the other hand, the repair-related changes in chromatin should be transient, and a particular chromatin state should be able to survive the repair process. Defects in the proper maintenance of chromatin states after repair could be a factor in the aging process, as well as in other pathologies.

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Tsuyoshi Ikura, Vasily V Ogryzko. Chromatin dynamics and DNA repair. Frontiers in Bioscience-Landmark. 2003. 8(6); 149-155.