Open Access
Article
The role of microsomal triglyceride transfer protein in lipoprotein assembly: an update
Ahmed Bakillah1,Ahmed El Abbouyi1
1
Biochemistry and Metabolism Department, Discovery Biology, Novo Nordisk A/S, Novo Nordisk Park, DK2760- Maaloev, Denmark. abak@novonordisk.com
DOI: 10.2741/1000 Volume 8 Issue 4, pp.294-305
Published: 01 January 2003
(This article belongs to the Special Issue Lipid binding, modifying and transferring proteins)
Abstract

The discovery of the role of MTP in mediating lipid transfer to apoB has greatly expanded our knowledge of the molecular mechanisms involved in apoB-containing lipoprotein assembly. In this review, advances referring to the structure, regulation and function of MTP are summarized and discussed. In addition to the well-known lipid transfer activity function, MTP has been shown to physically interact with apoB and this association appeared to be critically important in the regulation of lipoprotein production. Recent studies have provided insight into the paradoxical relationship between MTP polymorphism variants and metabolic disease. Genetic variants of MTP and their possible impact in the development of cardiovascular disease are discussed.

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Ahmed Bakillah, Ahmed El Abbouyi. The role of microsomal triglyceride transfer protein in lipoprotein assembly: an update. Frontiers in Bioscience-Landmark. 2003. 8(4); 294-305.