Frontiers in Bioscience-Landmark

Frontiers in Bioscience-Landmark (Landmark) is an international peer-reviewed open access journal of biological science. The journal integrates the art of science publication with a diverse array of information, tools, and techniques. Data and information that are useful to investigators in any discipline in biology and medicine including biochemistry, molecular biology, botany, agronomy, microbiology, parasitology, virology, immunology, biotechnology, marine biology, clinical and basic medicine, biomedical engineering, genetics, epidemiology and preventive medicine, ecology, entomology, bioinformatics will be published following peer review. This will include reviews and research articles in basic science and clinical science, as well as technical notes and protocols.

Open Access: Free for readers, with article processing charges (APC) paid by authors or their institutions.

High Visibility: Indexed by the Science Citation Index Expanded (Web of Science), MEDLINE (PubMed), Scopus, Current Contents - Life Sciences, Zoological Record, BIOSIS Previews, Index Medicus, Research Alert, Current Web Content, Chemical Abstracts and other databases.

Peer Review: Manuscripts are peer-reviewed and a first decision is provided to authors approximately 30 days after submission. Time from submission to acceptance is approximately 50-60 days.

For more information about Landmark.


Current Articles
Open Access
Editorial

Interaction of anti-diabetic medications and gut microbiota

Ru Chen, Sheng Pan
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.673-674
Managing Editor: Frontiers in Bioscience
DOI: 10.52586/4976 Published: 30 October 2021
Open Access
Comment

Co-signaling surface receptors: regulators of adaptive immune response. Comment on Shen H, et al. "Co-signaling receptors regulate T-cell plasticity and immune tolerance". Frontiers in Bioscience-Landmark. 2019; 24: 96–132

Alessandro Poggi
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.675-677
Managing Editor: Graham Pawelec
DOI: 10.52586/4977 Published: 30 October 2021
Open Access
Reply

Reply to Comment on Shen H, et al. “Co-signaling receptors regulate T-cell plasticity and immune tolerance”. Frontiers in Bioscience-Landmark. 2019; 24: 96–132

Haitao Shen, Na Wu, Gayani Nanayakkara, Hangfei Fu, Qian Yang, William Y. Yang, Angus Li, Yu Sun, Charles Drummer IV, Candice Johnson, Ying Shao, Luqiao Wang, Keman Xu, Wenhui Hu, Marion Chan, Vincent Tam, Eric T. Choi, Hong Wang, Xiaofeng Yang
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.678-679
Managing Editor: Graham Pawelec
DOI: 10.52586/4978 Published: 30 October 2021
Open Access
Commentary

Is miR therapeutic targeting still a miRage?

Elena Levantini
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.680-692
Managing Editor: Graham Pawelec
DOI: 10.52586/4979 Published: 30 October 2021
Open Access
Article

A phase II clinical trial with repeated intrathecal injections of autologous mesenchymal stem cells in patients with amyotrophic lateral sclerosis

Panayiota Petrou, Ibrahim Kassis, Nour Eddine Yaghmour, Ariel Ginzberg, Dimitrios Karussis
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.693-706
Managing Editor: Graham Pawelec
DOI: 10.52586/4980 Published: 30 October 2021
Open Access
Article

Expression and prognosis analysis of JMJD5 in human cancers

Hui Li, Qun Li, Hong Jing, Jianghai Zhao, Hui Zhang, Xuhui Ma, Lunshou Wei, Rujiang Dai, Weihong Sun, Zhimin Suo
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.707-716
Managing Editor: Graham Pawelec
DOI: 10.52586/4981 Published: 30 October 2021
Open Access
Article

Clinical features of pneumonia in severely malnourished children with diarrhoea compared to those without diarrhoea

Sufia Islam, Nishat Nasrin, Nigar Sultana Tithi, Christian Lehmann, Mohammod Jobayer Chisti
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.717-722
Managing Editor: Graham Pawelec
DOI: 10.52586/4982 Published: 30 October 2021
Open Access
Article

Characterization of multiscale logic operations in the neural circuits

JunHyuk Woo, Kiri Choi, Soon Ho Kim, Kyungreem Han, MooYoung Choi
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.723-739
Managing Editor: Graham Pawelec
DOI: 10.52586/4983 Published: 30 October 2021
Open Access
Article

Identification of key factors shaping integrated levels of ACE2 and TMPRSS2 expression in head and neck squamous cell carcinoma

Tianyu Zheng, Peipei Yue, Tongtong Han, Kaige Zhang, Yiming Jiang, Sijian Wang, Lulu Jiang, Baohong Zhao, Xinwen Zhang, Xu Yan
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.740-751
Managing Editor: Graham Pawelec
DOI: 10.52586/4984 Published: 30 October 2021
Open Access
Article

Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells

Oluremi I Adeniran, Mohammad A Mohammad, Sophie Featherby, Anthony Maraveyas, Andrew N Boa, Camille Ettelaie
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.752-764
Managing Editor: Silvia S. Barbieri
DOI: 10.52586/4985 Published: 30 October 2021
Open Access
Article

Expression of MHC class I polypeptide-related sequence A (MICA) in colorectal cancer

Ingrid Espinoza, Sumit Agarwal, Marcelo Sakiyama, Veena Shenoy, Wayne S. Orr, Sameer Al Diffalha, Anna Prizment, Sooryanarayana Varambally, Upender Manne, Christian R. Gomez
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.765-776
Managing Editor: Graham Pawelec
DOI: 10.52586/4986 Published: 30 October 2021
Open Access
Article

80MAP17 promotes the tumorigenesis of papillary thyroid carcinoma by reducing the stability of p53

Kun Yu, Hongjiang Lu, Yanhong Chen, Ying Xin, Zhuo Tan, Qiong Yang
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.777-788
Managing Editor: Elena Levantini
DOI: 10.52586/4987 Published: 30 October 2021
Open Access
Article

Effective inhibition of coronavirus replication by Polygonum cuspidatum

Huan Xu, Jing Li, Shidong Song, Zhen Xiao, Xuanqing Chen, Boxuan Huang, Mengsi Sun, Guoqing Su, Demin Zhou, Guanyu Wang, Ran Hao, Na Wang
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.789-798
Managing Editor: Alessandro Poggi
DOI: 10.52586/4988 Published: 30 October 2021
Open Access
Article

The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro

Xiao-Xin Gao, Chen-Hao Liu, Zhi-Lei Hu, Hai-Yin Li, Xian Chang, Yue-Yang Li, Yu-Yao Zhang, Yu Zhai, Chang-Qing Li
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.799-812
Managing Editor: Guoyao Wu
DOI: 10.52586/4989 Published: 30 October 2021
Open Access
Article

Exploration of the active components and pharmacological mechanism of Compound Longmaining for the treatment of myocardial infarction

Jia Li, Xiao Wang, Diaodiao Bu, Junbo Zou, Shining Xun, Yao Wang, Yanzuo Jia, Shangshang Yu, Wenfei Wang, Jiahui Zheng, Jiejun Hou, Xiaofei Zhang, Changli Wang
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.813-827
Managing Editor: Graham Pawelec
DOI: 10.52586/4990 Published: 30 October 2021
Open Access
Review

External visible characteristics prediction through SNPs analysis in the forensic setting: a review

Pamela Tozzo, Caterina Politi, Arianna Delicati, Andrea Gabbin, Luciana Caenazzo
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.828-850
Managing Editor: Cristoforo Pomara
DOI: 10.52586/4991 Published: 30 October 2021
Open Access
Review

Nanomaterials in Alzheimer’s disease treatment: a comprehensive review

Maryam Faiyaz, Mohd. Azhardin Ganayee, Salman Akhtar, Saravanan Krishnan, Bableen Flora, Deeksha Dogra, Niraj Kumar Jha, Dinesh Kumar Chellappan, Poonam Negi, Kamal Dua, Kavindra Kumar Kesari, Piyush Kumar Gupta
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.851-865
Managing Editor: Ghulam Md Ashraf
DOI: 10.52586/4992 Published: 30 October 2021
Open Access
Review

Tropism and transduction of oncolytic adenovirus vectors in prostate cancer therapy

Chuang Wu, Fu-kun Wei, Zi-yang Xu, Ru-min Wen, Jia-cun Chen, Jun-qi Wang, Li-jun Mao
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.866-872
Managing Editor: Graham Pawelec
DOI: 10.52586/4993 Published: 30 October 2021
Open Access
Review

Comparative safety and efficacy of molecular-targeted drugs, immune checkpoint inhibitors, hepatic arterial infusion chemotherapy and their combinations in advanced hepatocellular carcinoma: findings from advances in landmark trials

Yangxun Pan, Ruojing Wang, Dandan Hu, Wa Xie, Yizhen Fu, Jiajie Hou, Li Xu, Yaojun Zhang, Minshan Chen, Zhongguo Zhou
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.873-881
Managing Editor: Alessandro Poggi
DOI: 10.52586/4994 Published: 30 October 2021
Open Access
Review

Sarcopenia and perioperative management of elderly surgical patients

Yan Shi, Ling Zhou, Enshi Yan, Ling Yang, Chun Yang, Cunming Liu
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.882-894
Managing Editor: Elisa Belluzzi
DOI: 10.52586/4995 Published: 30 October 2021
Open Access
Review

Ten-eleven translocation proteins (TETs): tumor suppressors or tumor enhancers?

Cuili Ma, Hwanwook Seong, Yumei Liu, Xiao Yu, Shuanliang Xu, Yujing Li
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.895-915
Managing Editor: Graham Pawelec
DOI: 10.52586/4996 Published: 30 October 2021
Open Access
Review

Research progress in gene editing technology

Sheng Huang, Yali Yan, Fei Su, Xiaorui Huang, Dandan Xia, Xinxin Jiang, Yinghui Dong, Ping Lv, Fangyuan Chen, Yanwei Lv
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.916-927
Managing Editor: Alexandros G. Georgakilas
DOI: 10.52586/4997 Published: 30 October 2021
Open Access
Review

Approaches for the amelioration of adverse effects of drought stress on crop plants

Anamika Dubey, Ashwani Kumar, Muneer Ahmad Malla, Kanika Chowdhary, Garima Singh, Gudasalamani Ravikanth, Harish, Satyawati Sharma, Zaki Saati-Santamaria, Esther Menéndez, Joanna Felicity Dames
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.928-947
Managing Editor: Kevin Cianfaglione
DOI: 10.52586/4998 Published: 30 October 2021
Open Access
Review

Potential roles of mesenchymal stem cells and their exosomes in the treatment of COVID-19

Xiaoyun Cheng, Mao Jiang, Lingzhi Long, Jie Meng
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.948-961
Managing Editor: Graham Pawelec
DOI: 10.52586/4999 Published: 30 October 2021