Open Access
Article
The role of natural killer cells in cancer therapy
Sae Kyung Lee1,Stephan Gasser1
1
Immunology Programme, Centre for Life Sciences, National University of Singapore, Singapore 117456
DOI: 10.2741/E98 Volume 2 Issue 2, pp.380-391
Published: 01 January 2010
Abstract

Natural killer (NK) cells are innate immune cells that have long been known to be involved in the recognition and lysis of tumor cells. Despite significant gains in our understanding of the mechanisms that regulate NK cell function, the development of successful NK cell-based therapies has not yet been achieved. However, recent advances in our ability to modulate NK receptor signals and the sensitivity of tumor cells to NK cell-mediated lysis have led to a number of clinical trials testing novel methods to enhance NK cytotoxicity against cancer. Here, we present an overview of current therapies.

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Sae Kyung Lee, Stephan Gasser. The role of natural killer cells in cancer therapy. Frontiers in Bioscience-Elite. 2010. 2(2); 380-391.