Open Access
Article
Comparison of methods for statistical analysis of combination studies
Alexander N Donev1
1
School of Mathematics, University of Manchester, UK. a.n.donev@manchester.ac.uk
DOI: 10.2741/E87 Volume 2 Issue 1, pp.250-257
Published: 01 January 2010
Abstract

This paper is concerned with the statistical analysis of data obtained in studies of the joint action of drugs. The three methods that are compared are illustrated on real data (1), using the statistical package SAS. It is argued that while the results obtained using these methods do not differ substantially, the method allowing for estimating simultaneously all required parameters is to be preferred. It allows for a statistical test for the significance of the joint action of the drug combinations to be carried out.

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Alexander N Donev. Comparison of methods for statistical analysis of combination studies. Frontiers in Bioscience-Elite. 2010. 2(1); 250-257.