Open Access
Correlation of the virulence of CSFV with evolutionary patterns of E2 glycoprotein
Zhiyin Wu1,Qin Wang1,Qian Feng1,Yingying Liu1,Junlin Teng1,Albert Cheunghai Yu1,Jianguo Chen1
The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China
DOI: 10.2741/E83 Volume 2 Issue 1, pp.204-220
Published: 01 January 2010

Infection with classical swine fever virus (CSFV) is costly to the livestock industry. Several genomic sequences including velogenic strains and low virulent strains have been identified. However, the reasons for the virulence of the virus have remained unclear. Based on selective pattern and pressure strength, we classified all genes of CSFV into three classes. Among these genes, the E2 gene was under the strongest positive selection. Based on the analysis of 85 representative E2 gene sequences, the location and intensity of positive selection in CSFV isolates from group one and group two were identified. These results suggest that these two groups employ evolutionary difference. Moreover, the mutations, potentially driven by positive selection, can be correlated with the virulence of CSFV by altering the conformation and function of E2 and/or changing its glycosylation pattern. Based on these results, a model for the evolution of virulence of CSFV is proposed. The results provide a link between epidemiology and the gene function of CSFV, and may shed light on the molecular mechanism underlying the variation of CSFV virulence.

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Zhiyin Wu, Qin Wang, Qian Feng, Yingying Liu, Junlin Teng, Albert Cheunghai Yu, Jianguo Chen. Correlation of the virulence of CSFV with evolutionary patterns of E2 glycoprotein. Frontiers in Bioscience-Elite. 2010. 2(1); 204-220.