Open Access
Physical exercise reduces synthesis of ADMA, SDMA, and L-Arg
Graziano Riccioni1,*,Luca Scotti2,Maria Teresa Guagnano3,Gabriella Bosco3,Valentina Bucciarelli2,Emanuela Di Ilio2,Lorenza Speranza3,Filippo Martini2,Tonino Bucciarelli2
Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy
Clinical Biochemistry, Department of Biomedical Science, G. D’Annunzio, University of Chieti, Italy
Department of Internal Medicine and Aging Science, University G. D’Annunzio, Chieti, Italy
DOI: 10.2741/E739 Volume 7 Issue 3, pp.417-422
Published: 01 June 2015
(This article belongs to the Special Issue Biochemical markers in biological fluids)
*Corresponding Author(s):  
Graziano Riccioni

Increased levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and low plasma level of L-arginine (L-ARG) are all conditions likely to decrease nitric oxide (NO) production. Aim of this study is to evaluate ADMA, SDMA, and L-ARG plasmatic levels before and after physical exercise in patients with coronary artery disease (CAD). We studied 30 patient with mean age 52 ± 4.5 years. After inclusion in the study, before the execution of physical exercise, heparinized blood sample was drawn from an indwelling arterial line for determination of ADMA, L-ARG and SDMA (baseline values). Subsequently a blood sample was drawn after the physical exercise. The mean plasma concentrations of ADMA (0.68 ± 0.06 vs 0.48 ± 0.05 µmol/L) and SDMA (0.45 ± 0.03 vs 0.30 ± 0.03 µmol/L) were significantly lower after physical exercise in comparison to baseline value, while L-ARG mean levels were increased (44.20 ± 10.5 vs 74.13 ± 11.2 µmol/L). Physical exercise has a beneficial effect by reducing plasmatic ADMA and SDMA levels, and increasing L-ARG substrate for endothelial NO.

Key words

ADMA, SDMA L-arginine, Nitric Oxide, Coronary Artery Disease, Physical Exercise

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Graziano Riccioni, Luca Scotti, Maria Teresa Guagnano, Gabriella Bosco, Valentina Bucciarelli, Emanuela Di Ilio, Lorenza Speranza, Filippo Martini, Tonino Bucciarelli. Physical exercise reduces synthesis of ADMA, SDMA, and L-Arg. Frontiers in Bioscience-Elite. 2015. 7(3); 417-422.