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Physical exercise reduces synthesis of ADMA, SDMA, and L-Arg
Graziano Riccioni1,*,Luca Scotti2,Maria Teresa Guagnano3,Gabriella Bosco3,Valentina Bucciarelli2,Emanuela Di Ilio2,Lorenza Speranza3,Filippo Martini2,Tonino Bucciarelli2
1
Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy
2
Clinical Biochemistry, Department of Biomedical Science, G. D’Annunzio, University of Chieti, Italy
3
Department of Internal Medicine and Aging Science, University G. D’Annunzio, Chieti, Italy
DOI: 10.2741/E739 Volume 7 Issue 3, pp.417-422
Published: 01 June 2015
(This article belongs to the Special Issue Biochemical markers in biological fluids)
*Corresponding Author(s):  
Graziano Riccioni
E-mail:  
griccionI@hotmail.com
Abstract

Increased levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and low plasma level of L-arginine (L-ARG) are all conditions likely to decrease nitric oxide (NO) production. Aim of this study is to evaluate ADMA, SDMA, and L-ARG plasmatic levels before and after physical exercise in patients with coronary artery disease (CAD). We studied 30 patient with mean age 52 ± 4.5 years. After inclusion in the study, before the execution of physical exercise, heparinized blood sample was drawn from an indwelling arterial line for determination of ADMA, L-ARG and SDMA (baseline values). Subsequently a blood sample was drawn after the physical exercise. The mean plasma concentrations of ADMA (0.68 ± 0.06 vs 0.48 ± 0.05 µmol/L) and SDMA (0.45 ± 0.03 vs 0.30 ± 0.03 µmol/L) were significantly lower after physical exercise in comparison to baseline value, while L-ARG mean levels were increased (44.20 ± 10.5 vs 74.13 ± 11.2 µmol/L). Physical exercise has a beneficial effect by reducing plasmatic ADMA and SDMA levels, and increasing L-ARG substrate for endothelial NO.

Key words

ADMA, SDMA L-arginine, Nitric Oxide, Coronary Artery Disease, Physical Exercise

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Graziano Riccioni, Luca Scotti, Maria Teresa Guagnano, Gabriella Bosco, Valentina Bucciarelli, Emanuela Di Ilio, Lorenza Speranza, Filippo Martini, Tonino Bucciarelli. Physical exercise reduces synthesis of ADMA, SDMA, and L-Arg. Frontiers in Bioscience-Elite. 2015. 7(3); 417-422.