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Andrographolide and analogues in cancer prevention
Siddhartha Kumar Mishra1,*,Swati Tripathi2,Archana Shukla1,Seung Hyun Oh3,Hwan Mook Kim3
1
Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar 470003, India,
2
Vegetable Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Suwon 440706, Republic of Korea,
3
Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 406840, Republic of Korea
DOI: 10.2741/E732 Volume 7 Issue 2, pp.293-304
Published: 01 January 2015
(This article belongs to the Special Issue Frontiers in modern biology)
*Corresponding Author(s):  
Siddhartha Kumar Mishra
E-mail:  
siddharthakm@yahoo.com
Abstract

Andrographis paniculata is a medicinal plant traditionally used for treatment of cough and cold, fever, laryngitis, and several infectious diseases. Extracts of A. paniculata have shown versatile potency against various diseases including cancer. The active biomolecules of A. paniculata mainly are lactone and diterpene. Andrographolide and analogues have been widely used for prevention of different diseases. Andrographolides have shown potent antiinflammatory and anticancer activities. It showed potentials as chemopreventive agents by suppressing growth of cancer cells by inhibiting NF-κB, PI3K/AKT and other kinase pathways and by inducing apoptosis. Andrographolide induced both intrinsic and extrinsic apoptosis pathway in different cancer cells via expression of different anti-apoptotic protein like Bax, p53, and activated caspases. Andrographolide was successfully used as an antineoplastic drug in cancer chemotherapy. Andrographolide inhibited the growth of human breast, prostate, and hepatoma tumors. Andrographolide and analogues need to be subjected to further clinical and biomedical studies in cancer chemoprevention. Andrographolide could be potent anticancer agent when used in combination with other chemotherapeutic agents.

Key words

Andrographis paniculata, Andrographolide, Anticancer, Antiinflammation, Apoptosis Induction, Cell Cycle Arrest, Cancer Prevention, Review

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Siddhartha Kumar Mishra, Swati Tripathi, Archana Shukla, Seung Hyun Oh, Hwan Mook Kim. Andrographolide and analogues in cancer prevention. Frontiers in Bioscience-Elite. 2015. 7(2); 293-304.