Understanding the functional discrepancy of Pim-1 in cancer
Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University,
PO Box 35, PC 123, Al Khoud, Sultanate of Oman
Department of Biochemistry, College of
Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al Khoud, Sultanate
01 January 2015
The Pim-1 gene encodes for a serine/threonine protein kinase proto-oncogene involved in cytokine signaling as well as in various pathways
regulating cell cycle and apoptosis. Pim-1 kinase plays an important role in the development of various tumors mainly, prostate cancer, Burkitt’s lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.
Pim-1 Kinase, Prostate Cancer, CAMKs, Inhibitors, Review
Share and Cite
Allal Ouhtit, Sukalp Muzumdar, Ishita Gupta, Somya Shanmuganathan, Yahya Tamimi. Understanding the functional discrepancy of Pim-1 in cancer. Frontiers in Bioscience-Elite. 2015. 7(2); 239-247.