Open Access
Natural supplements for improving insulin sensitivity and glucose uptake in skeletal muscle
Samir A. Kouzi1,*,Sendra Yang1,Donald S. Nuzum1,Amie J. Dirks-Naylor1
School of Pharmacy, Levine College of Health Sciences, Wingate University, Wingate, North Carolina 28174
DOI: 10.2741/E720 Volume 7 Issue 1, pp.107-121
Published: 01 January 2015
(This article belongs to the Special Issue Mechanisms of skeletal muscle dysfunction and preventative measures)
*Corresponding Author(s):  
Samir A. Kouzi

Type 2 diabetes is a common metabolic disorder characterized by resistance to the actions of insulin to stimulate skeletal muscle glucose disposal. In light of the staggering financial/human cost of type 2 diabetes, there is considerable need for safe and effective agents that can be used to prevent and/or adjunctively treat the disease. Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population. The evidence also suggests that, when used adjunctively, these natural products are likely to help clinicians achieve optimal glycemic control, improve long-term prognosis, and/or minimize the need for insulin therapy in type 2 diabetics. More research, particularly well-designed, long-term human clinical trials, is certainly needed to accurately define the value and place of these supplements in diabetes prevention and management.

Key words
Type 2 diabetes mellitus,Natural products,Dietary supplements,Skeletal muscle,Insulin resistance,Review
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Samir A. Kouzi, Sendra Yang, Donald S. Nuzum, Amie J. Dirks-Naylor. Natural supplements for improving insulin sensitivity and glucose uptake in skeletal muscle. Frontiers in Bioscience-Elite. 2015. 7(1); 107-121.