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HPV and CSC in HNSCC cisplatin resistance
Vishnu Modur1,K. Thomas Robbins1,Krishna Rao1,*
1
SIU School of Medicine, Springfield, IL, 62702, USA
DOI: 10.2741/E717 Volume 7 Issue 1, pp.66-76
Published: 01 January 2015
*Corresponding Author(s):  
Krishna Rao
E-mail:  
krao@siumed.edu
Abstract

Cisplatin (DNA intercalator), a standard chemotherapy drug often used to treat head and neck squamous cellular carcinoma (HNSCC) has very low response rates in recurrent disease of HNSCC, this is a major clinical problem today. However, a valuable window to look in to the underlying molecular aspects of a favorable and unfavorable cisplatin response is offered by a distinct disease entity in HNSCC – HPV+ OPSCC. It responds far more favorably to cisplatin than non-HPV driven HNSCC. Another intriguing aspect of head and neck cancer biology is the emergence of the CD44+ cancer stem cell - the tumor initiating population that in all likelihood is the root cause of therapeutic resistance. The critical question is, are there any differences between the CD44+ CSC population of an HPV+ OPSCC and a non-HPV HNSCC? In this regard, the inverse relation between EGFR levels and HPV status in OPSCC may be a common thread that connects the better response rates of HPV+ OPSCC with the contribution of CD44+ stem cells of HNSCC to chemoresistance.

Key words
HNSCC,Head And Neck Cancer,Cancer stem cells,Cisplatin,HPV,EGFR,CD44,Review
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Vishnu Modur, K. Thomas Robbins, Krishna Rao. HPV and CSC in HNSCC cisplatin resistance. Frontiers in Bioscience-Elite. 2015. 7(1); 66-76.