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Role of agmatine in neurodegenerative diseases and epilepsy
Morgana Moretti1,Filipe C Matheus1,Paulo A de Oliveira1,Vivian B Neis1,Juliana Ben1,Roger Walz2,Ana Lucia S Rodrigues3,Rui Daniel Prediger1,*
1
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
2
Departamento de Clinica Medica, Hospital Universitario, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
3
Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
DOI: 10.2741/E710 Volume 6 Issue 2, pp.341-359
Published: 01 June 2014
(This article belongs to the Special Issue Current advances in epilepsy and neurodegeneration)
*Corresponding Author(s):  
Rui Daniel Prediger
E-mail:  
ruidsp@hotmail.com
Abstract

Agmatine, a cationic polyamine synthesized after decarboxylation of L-arginine by the enzyme arginine decarboxylase, is an endogenous neuromodulator that emerges as a potential agent to manage diverse central nervous system (CNS) disorders. Consistent with its neuromodulatory and neuroprotective properties, there is increasing number of preclinical studies demonstrating the beneficial effects of exogenous agmatine administration on depression, anxiety, hypoxic ischemia, nociception, morphine tolerance, memory, Parkinson's disease, Alzheimer`s disease, traumatic brain injury related alterations/disorders and epilepsy. The aim of this review is to summarize the knowledge about the effects of agmatine in CNS and point out its potential as new pharmacological treatment for diverse neurological and neurodegenerative diseases. Moreover, some molecular mechanisms underlying the neuroprotective effects of agmatine will be discussed.

Key words

Agmatine, Depression, Neurodegenerative Disease, Neuroprotection, Epilepsy, Review

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Morgana Moretti, Filipe C Matheus, Paulo A de Oliveira, Vivian B Neis, Juliana Ben, Roger Walz, Ana Lucia S Rodrigues, Rui Daniel Prediger. Role of agmatine in neurodegenerative diseases and epilepsy. Frontiers in Bioscience-Elite. 2014. 6(2); 341-359.