Open Access
Biochemical characteristics and risk factors in non-alcoholic fatty liver
Ying Wang1,Jin Dong1,Hong-ying Liu1,De-qing Wang1,Ya-ping Tian1
Department of Clinical Biochemistry, Chinese PLA General Hospital, No 28, Fuxing Road, Beijing, China
DOI: 10.2741/E71 Volume 2 Issue 1, pp.105-110
Published: 01 January 2010
(This article belongs to the Special Issue Biosensors and their applications)

Non-alcoholic fatty liver disease (NAFLD) is a condition associated with metabolic disturbances. The aim of the present study was to investigate the biochemical characteristics and risk factors for NAFLD. The study was carried out in a total of 881 subjects diagnosed by ultrasonography. NAFLD occurred mainly in middle-aged individuals, with a prevalence of 63.1 per cent. Multiple logistic regression analysis showed that male gender, presence of obesity, hypertension, dyslipidemia, or Type 2 diabetes and elevated serum alanine transaminase activities were independent risk factors for the development of NAFLD. Subjects with NAFLD were obese, hypertensive and often had signs of disturbances in lipid and glucose metabolism and abnormalities in hepatic functions. These findings show risk factors in the development and offer opportunities for prevention of NAFLD.

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Ying Wang, Jin Dong, Hong-ying Liu, De-qing Wang, Ya-ping Tian. Biochemical characteristics and risk factors in non-alcoholic fatty liver. Frontiers in Bioscience-Elite. 2010. 2(1); 105-110.