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Bridging between transplantation therapy and neurotrophic factors in Parkinson's disease
Biswarup Ghosh1,Chen Zhang2,George. M. Smith1,*
1
Center for Neural Repair and Rehabilitation, Department of Neuroscience, and Shriners Hospitals for Pediatric Research, Temple University, School of Medicine, Philadelphia, PA 19140-4106, USA
2
Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
DOI: 10.2741/E704 Volume 6 Issue 2, pp.225-235
Published: 01 June 2014
(This article belongs to the Special Issue Parkinsons disease)
*Corresponding Author(s):  
George. M. Smith
E-mail:  
george.smith@temple.edu
Abstract

Parkinson's disease (PD) represents a challenging condition where different therapeutic options have evolved over the course of the last 50 years. The potential for therapeutic use of cell transplantation for cell replacement or for gene delivery of neurotrophic factors has received a great deal of attention. Currently, all available treatment options are directed towards the amelioration of symptoms. A greater understanding of the distinctive pathology underlying PD might offer some novel therapeutic approaches. Transplantation of embryonic ventral mesencephalon (VM) dopaminergic neurons has shown promise in animal studies, but similar transplant procedures have shown limited success in clinical trials. One important issue may be the site of transplantation. Previous studies have transplanted VM into the striatum, which is the target of these neurons. With increased understanding of growth and guidance molecule effecting dopaminergic neurons, it may be feasible to place transplants in the damaged substantia nigra and direct the growth of axons into target regions to reconstruction of midbrain dopamine (DA) circuitry. Our established and on-going understanding of the molecular cues which support directed growth of DA neurons form an important basis for the refinement and optimization of VM grafting procedures, and also the development of new procedures based on the use of stem cells. In this review, we discuss transplantation therapy and how selective guidance molecules could be used to reconstruction of nigrostriatal circuit.

Key words

Neurotrophins, Parkinson’s Disease, Dopamine, Transplants, Netrin, Review

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Biswarup Ghosh, Chen Zhang, George. M. Smith. Bridging between transplantation therapy and neurotrophic factors in Parkinson's disease. Frontiers in Bioscience-Elite. 2014. 6(2); 225-235.