Bio-effects of non-ionizing electromagnetic fields in context of cancer therapy
Department of Regenerative Medicine and Artificial Organs, PE “Center for Life Sciences”, JSC Nazarbayev University, Unit 9, 53 Kabanbay batyr Ave., Astana 010000, Kazakhstan
Department of Anatomy, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Fukuoka 814-0180, Japan
Biomaterials and Medical Devices Research Group, School of Pharmacy and Biomedical Sciences, University of Brighton, Cockcroft Building, Lewes Road, Brighton, BN2 4GJ, United Kingdom
School of Engineering, JSC Nazarbayev University, Unit 6, 53 Kabanbay batyr Ave., Astana 010000, Kazakhstan
Nanoscience and Nanotechnology Group, Faculty of Science & Engineering, University of Brighton, Cockcroft Building, Lewes Road, Brighton, BN2 4GJ, United Kingdom
01 January 2014
Bio-effects mediated by non-ionizing electromagnetic fields (EMF) have become a hot topic of research in the last decades. This interest has been triggered by a growing public concern about the rapid expansion of telecommunication devices and possible consequences of their use on human health. Despite a feasibility study of potential negative impacts, the therapeutic advantages of EMF could be effectively harnessed for the treatment of cancer and other diseases. This review aims to examine recent findings relating to the mechanisms of action underlying the bio-effects induced by non-ionizing EMF. The potential of non-thermal and thermal effects is discussed in the context of possible applications for the induction of apoptosis, formation of reactive oxygen species, and increase of membrane permeability in malignant cells. A special emphasis has been put on the combination of EMF with magnetic nano-particles and ultrasound for cancer treatment. The review encompasses both human and animal studies.
Electromagnetic Field; bio-effect; DNA; Apoptosis; Reactive Oxygen Species; Cancer; Drug Delivery; Nanoparticle; Ultrasound; Combined Therapy; Review
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Timur Saliev, Katsuro Tachibana, Denis Bulanin, Sergey Mikhalovsky, Ray D.L. Whitby. Bio-effects of non-ionizing electromagnetic fields in context of cancer therapy. Frontiers in Bioscience-Elite. 2014. 6(1); 175-184.