Open Access

Effects of early endometriosis on IVF-ET outcomes

Keiko Mekaru1,*,Chiaki Yagi1,Kozue Asato1,Hitoshi Masamoto1,Kaoru Sakumoto1,Yoichi Aoki1
Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan
DOI: 10.2741/E652 Volume 5 Issue 2, pp.720-724
Published: 01 January 2013
(This article belongs to the Special Issue Frontiers in endometriosis)
*Corresponding Author(s):  
Keiko Mekaru

There have been very few reports on the outcomes of in vitro fertilization and embryo transfer (IVF- ET) in women with stage I/II endometriosis. The objective of this study was to investigate IVF-ET outcomes in women with early-stage endometriosis. We enrolled 35 women less than 40 years with unexplained infertility who underwent IVF-ET into the study. We compared 18 women with stage I/II endometriosis according to the revised American Society for Reproductive Medicine classification for endometriosis, who underwent 39 IVF-ET cycles [En (+) group] with 17 women without endometriosis who underwent 41 IVF-ET cycles [En (−) group]. Higher requirements of total gonadotropin, a lower percentage of high-quality embryos of all fertilized eggs (9.0% vs. 16.3%), a relatively lower pregnancy rate (33.3% vs. 41.5%), and a lower live birth rate (25.6% vs. 34.1%) were observed in the En (+) group. Although no significant effect on IVF-ET outcome was observed, ovarian response may be decreased in women with stage I/II endometriosis. Considering the decreased number of high-quality embryos in the En (+) group, stage I/II endometriosis may have detrimental effects on embryo quality.

Key words

Early endometriosis, In vitro fertilization and embryo transfer, Laparoscopy

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Keiko Mekaru, Chiaki Yagi, Kozue Asato, Hitoshi Masamoto, Kaoru Sakumoto, Yoichi Aoki. Effects of early endometriosis on IVF-ET outcomes. Frontiers in Bioscience-Elite. 2013. 5(2); 720-724.