Open Access
Article
Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy
Pasquale Florio1,Alessandro Frigiola1,Raffaele Battista1,Ali El Hadi Abdalla1,Diego Gazzolo1,Letizia Galleri1,Serena Pinzauti1,Raul Abella1,Giovanni Li Volti1,Mirella Strambi1
1
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy. florio@unisi.it
DOI: 10.2741/E62 Volume 2 Issue 1, pp.36-42
Published: 01 January 2010
(This article belongs to the Special Issue Clinical and biochemical markers and fetal-neonatal development)
Abstract

Activin-A is a protein over-expressed and secreted by the brain after neuronal destruction. We evaluated whether serum activin-A increases in asphyxiated full-term newborns (AFTNs) at risk of hypoxic-ischemic-encephalopathy (HIE). 105 consecutive infants (35 affected by perinatal asphyxia due to acute fetal distress; 70 healthy gestational-age matched newborns) underwent cranial assessment and neurologic examination at 12, 24 and 72 hours after birth and, on discharge from the hospital and; activin-A and monitoring laboratory variables assessment at birth. According to the occurrence of HIE within 7-days after birth, AFTNs were subdivided in Group A (n= 20; no/mild HIE with good prognosis) and Group B (n= 15; moderate/severe HIE with a greater risk of neurological handicap). Activin-A was significantly (P less than 0.0001) higher in Groups A and B than controls and highest (P less than 0.001) in Group B. At 0.66 ng/L activin-A achieved a sensitivity of 93.33 per cent and a specificity of 96.63 per cent, respectively, as HIE diagnostic test. These findings show that activin A increased in AFTNs with HIE before the appearance of related signs.

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Pasquale Florio, Alessandro Frigiola, Raffaele Battista, Ali El Hadi Abdalla, Diego Gazzolo, Letizia Galleri, Serena Pinzauti, Raul Abella, Giovanni Li Volti, Mirella Strambi. Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. Frontiers in Bioscience-Elite. 2010. 2(1); 36-42.