Open Access
Article
Molecular interactions in extracellular matrix of tendon
Evgenia Karousou1,Mario Ronga1,Davide Vigetti1,Daniele Barcolli1,Alberto Passi1,Nicola Maffulli1
1
Department of Experimental Biomedical and Clinical Sciences (DSBSC), University of Insubria, Varese, Italy
DOI: 10.2741/E59 Volume 2 Issue 1, pp.1-12
Published: 01 January 2010
(This article belongs to the Special Issue Tendons: the next frontier)
Abstract

Tendon is a poorly vascularized and highly specialized connective tissue containing few scattered cells that play an important role in the musculoskeletal apparatus by resisting mechanical stress. Because of the slow rate of the metabolism of its molecular components, the tendon gradually loses its mechanical properties and may rupture upon an array of physical activities. In this report, we discuss the molecular changes involved in the extracellular matrix-tendon interactions leading to tissue degeneration and rupture.

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Evgenia Karousou, Mario Ronga, Davide Vigetti, Daniele Barcolli, Alberto Passi, Nicola Maffulli. Molecular interactions in extracellular matrix of tendon. Frontiers in Bioscience-Elite. 2010. 2(1); 1-12.