Open Access

Stem cell theory for the pathogenesis of endometriosis

Tetsuo Maruyama1,*,Yasunori Yoshimura1
Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
DOI: 10.2741/E589 Volume 4 Issue 8, pp.2754-2763
Published: 01 June 2012
(This article belongs to the Special Issue Frontiers in endometriosis)
*Corresponding Author(s):  
Tetsuo Maruyama

Proposed hypothetical causes of endometriosis include retrograde menstruation, lymphatic and vascular metastasis, iatrogenic direct implantation, coelomic metaplasia, embryonic rest, and mesenchymal cell differentiation (induction). Each theory, individually, fails to account for all types of endometriotic lesions, thereby implicating combined and/or type-specific mechanisms. Recent evidence supports the presence of endometrial stem/progenitor cells and their possible involvement in eutopic endometrial regeneration and differentiation. Thus an additional novel mechanism for the origin of endometriotic lesions is that they arise from ectopic endometrial stem/progenitor cells.

Key words

Endometriosis, Endometrium, Stem, Progenitor Cells, Pathogenesis, Implantation, Metaplasia, Bone Marrow, Regeneration, Endothelial Progenitor Cells, Endothelial Cells, Review

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Tetsuo Maruyama, Yasunori Yoshimura. Stem cell theory for the pathogenesis of endometriosis. Frontiers in Bioscience-Elite. 2012. 4(8); 2754-2763.