Open Access
Article

High sensitive troponin T in individuals with chest pain of presumed ischemic origin

Giovanni Cuda1,*,Margherita Lentini1,Luigia Gallo1,Fortunata G. Lucia1,Lorenzina Giaquinto Carinci1,Serafina Mancuso1,Rosa A. Biondi1,Raffaella Sinopoli1,Rita Casadonte1,Pietro H. Guzzi2,Mario Cannataro2,Annalisa Mongiardo3,Claudio Iaconetti3,Angela Bochicchio3,Antonio Curcio3,Daniele Torella3,Pietroantonio Ricci4,Ciro Indolfi3,Francesco Costanzo1
1
Laboratory of Clinical Biochemistry and Molecular Biology, Fondazione, T. Campanella, University of Magna Graecia, Catanzaro, Italy
2
Laboratory of Bioinformatics, University of Magna Graecia, Catanzaro, Italy
3
Division of Cardiology, University of Magna Graecia, Catanzaro, Italy
4
Division of Forensic Medicine, University of Magna Graecia, Catanzaro, Italy
DOI: 10.2741/E544 Volume 4 Issue 7, pp.2322-2327
Published: 01 June 2012
(This article belongs to the Special Issue Biochemical markers in biological fluids)
*Corresponding Author(s):  
Giovanni Cuda
E-mail:  
cuda@unicz.it
Abstract

This study was aimed at assessing the bias of high sensitive cardiac troponin T vs. the standard cardiac troponin T in a selected population with chest pain of presumed cardiac origin. Serum cTnT was determined in 132 patients and in 106 apparently healthy controls by both assays. The hs-cTnT outperformed the standard generation assay by: i) allowing a larger and earlier diagnosis of AMI (74.2% vs. 64.3% patients resulted positive at the final diagnosis of AMI when tested with the hs-cTnT or the stdcTnT assay, respectively); ii) showing a better timedependent dynamics in patients with AMI due to a higher precision at low concentrations; iii) identifying, within the controls, 6 subjects in whom a further examination revealed the presence of chronic asymptomatic cardiac ischemia. The results underscore the excellent performance of the hscTnT assay in our population. The use of this test can thus be strongly recommended in subjects presenting to the emergency unit with chest pain of presumed ischemic origin in order to increase the probability of earlier diagnosis of AMI, especially in non-STEMI.

Key words

Cardiac troponin T, Acute myocardial infarction, Coronary artery disease, Early diagnosis, Biomarkers

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Giovanni Cuda, Margherita Lentini, Luigia Gallo, Fortunata G. Lucia, Lorenzina Giaquinto Carinci, Serafina Mancuso, Rosa A. Biondi, Raffaella Sinopoli, Rita Casadonte, Pietro H. Guzzi, Mario Cannataro, Annalisa Mongiardo, Claudio Iaconetti, Angela Bochicchio, Antonio Curcio, Daniele Torella, Pietroantonio Ricci, Ciro Indolfi, Francesco Costanzo. High sensitive troponin T in individuals with chest pain of presumed ischemic origin. Frontiers in Bioscience-Elite. 2012. 4(7); 2322-2327.