High sensitive troponin T in individuals with chest pain of presumed ischemic origin
This study was aimed at assessing the bias of high sensitive cardiac troponin T vs. the standard cardiac troponin T in a selected population with chest pain of presumed cardiac origin. Serum cTnT was determined in 132 patients and in 106 apparently healthy controls by both assays. The hs-cTnT outperformed the standard generation assay by: i) allowing a larger and earlier diagnosis of AMI (74.2% vs. 64.3% patients resulted positive at the final diagnosis of AMI when tested with the hs-cTnT or the stdcTnT assay, respectively); ii) showing a better timedependent dynamics in patients with AMI due to a higher precision at low concentrations; iii) identifying, within the controls, 6 subjects in whom a further examination revealed the presence of chronic asymptomatic cardiac ischemia. The results underscore the excellent performance of the hscTnT assay in our population. The use of this test can thus be strongly recommended in subjects presenting to the emergency unit with chest pain of presumed ischemic origin in order to increase the probability of earlier diagnosis of AMI, especially in non-STEMI.
Cardiac troponin T, Acute myocardial infarction, Coronary artery disease, Early diagnosis, Biomarkers