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Biomarkers of oxidative stress in babies at high risk for retinopathy of prematurity
Serafina Perrone1,Piero Vezzosi1,Mariangela Longini1,Barbara Marzocchi1,Patrizia Paffetti1,Carlo V Bellieni1,Stefano Martinelli1,Giuseppe Buonocore1
1
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
DOI: 10.2741/E52 Volume 1 Issue 2, pp.547-552
Published: 01 June 2009
(This article belongs to the Special Issue Clinical and biochemical markers and fetal-neonatal development)
Abstract

Oxygen-induced oxidative stress (OS) has damaging effects in the perinatal period. For now there is a lake of evidence that OS occurs in babies with retinopathy of prematurity (ROP) We tests the hypothesis that a strict oxygen policy may minimize postnatal OS reducing severity of ROP. Multicenter prospective cohort study (72 newborns), using a common clinical management protocol with a strict control of oxygen administration. Assessment of biochemical markers of OS in blood samples at birth and on days 7, 14, and 21. Sixteen babies (22.2 per cent) developed ROP stage 1-2. No severe form of ROP was observed. Birth weight and O2 administration in delivery room were the factors significantly associated with the development of ROP stage 1-2. Prematurity and O2 administration in delivery room are the main factors coming into play in the course of ROP. Because room air is richer in oxygen than intrauterine environment, higher OS can be minimized, as well as incidence and severity of ROP, using standardized management with a restricted oxygen breathing policy.

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Serafina Perrone, Piero Vezzosi, Mariangela Longini, Barbara Marzocchi, Patrizia Paffetti, Carlo V Bellieni, Stefano Martinelli, Giuseppe Buonocore. Biomarkers of oxidative stress in babies at high risk for retinopathy of prematurity. Frontiers in Bioscience-Elite. 2009. 1(2); 547-552.