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Immunomodulatory effects of chemokines during the early implantation window
Laura Fraccaroli1,Julio Alfieri1,Claudia Perez Leiros1,Rosanna Ramhorst1
1
Immunopharmacology Laboratory, School of Exact and Natural Sciences, Int. Guiraldes 2160, Ciudad Universitaria, Pabellon 2 Piso 4, (C1428EHA) University of Buenos Aires, Argentina
DOI: 10.2741/E28 Volume 1 Issue 1, pp.288-298
Published: 01 June 2009
Abstract

Successful implantation requires a functionally normal embryo at the blastocyst stage and a receptive endometrium as well as adequate communication between them throughout the implantation process. This cross-talk is highly regulated by a number of different kinds of molecules. Particularly, chemokines, small polypeptides that attract specific leukocyte subsets by binding to cell-surface receptors, are also required to maintain immune-privileged sites as the feto-maternal interface. Chemokines expression involves an interdependent network with the absence of a single chemokine affecting the expression of multiple other chemokines, we have chosen to focus on just two representative examples: RANTES (regulated on normal T cell expressed and secreted) and MCP-1 (Monocyte chemo-attractant protein). Here, we present updated information on their expression levels and regulation on three different levels: 1) systemic effects on maternal allogeneic response; 2) local effects on endometrial cells; and 3) during an early stage of the feto-maternal dialogue. For each of the three levels, we analyzed data from both fertile women and patients having experienced recurrent spontaneous abortions as representative of physiological and pathological situations respectively.

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Laura Fraccaroli, Julio Alfieri, Claudia Perez Leiros, Rosanna Ramhorst. Immunomodulatory effects of chemokines during the early implantation window. Frontiers in Bioscience-Elite. 2009. 1(1); 288-298.