Open Access
BCL-2: pro-or anti-oxidant?
Zhi Xiong Chen1,Shazib Pervaiz1
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
DOI: 10.2741/E25 Volume 1 Issue 1, pp.263-268
Published: 01 June 2009
(This article belongs to the Special Issue Apoptosis and mitochondria)

Bcl-2 is recognized as an oncoprotein via its ability to impede death signaling by sequestrating pro-apoptotic proteins such as Bax and Bak as well as preserving mitochondrial outer membrane integrity. Recently, a growing body of evidence has evaluated the role of Bcl-2 in intracellular redox regulation and its downstream effects on life and death decisions in cancer cells. On the backdrop of these findings, we discuss here the classical anti-apoptotic role of Bcl-2 in malignant cells, and review the significance of Bcl-2-mediated regulation of tumor redox status. We discuss recent evidence that underscores a paradigm shift in the way cellular redox status impacts cell fate decisions via the effect of Bcl-2 on mitochondrial physiology. The ability of Bcl-2 to promote, modulate and optimize mitochondrial respiration under different redox states highlights the importance of mitochondrial bioenergetics, ROS and the roles they might play in the onset and/or maintenance of oncogenesis.

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Zhi Xiong Chen, Shazib Pervaiz. BCL-2: pro-or anti-oxidant?. Frontiers in Bioscience-Elite. 2009. 1(1); 263-268.