Open Access
Pluripotent stem cell-derived dendritic cells for immunotherapy
Satoru Senju1,Yusuke Matsunaga1,Satoshi Fukushima1,Shinya Hirata1,Hidetake Matsuyoshi1,Yasuharu Nishimura1
The Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
DOI: 10.2741/E211 Volume 2 Issue 4, pp.1520-1527
Published: 01 June 2010
(This article belongs to the Special Issue Regenerative medicine immunity)

Dendritic cell (DC) is regarded as a powerful means for anti-cancer immunotherapy. Clinical trials of cancer therapy with DC loaded with cancer antigens, such as tumor cell-lysates or HLA class I-binding antigenic peptides, have been conducted. Antigen-specific negative manipulation of the immune response by DC is a potential treatment for autoimmune diseases and also for control of allo-reactive immune responses in transplantation medicine. Currently, DC for clinical use are generated from peripheral blood monocytes of the patients. However, the number of monocytes obtained from the patients is limited and the potential of monocytes to differentiate into DC varies depending on the blood donor. Thus, the issue of limited cells is a serious obstacle for DC therapy. ES cells and iPS cells have pluripotency and unlimited propagation capacity and may be an ideal cell source for DC-therapy. Several groups, including us, have developed methods to generate DC from ES cells or iPS cells. This review introduces the studies on generation, characterization, and genetic modification of DC derived from ES cells or iPS cells.

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Satoru Senju, Yusuke Matsunaga, Satoshi Fukushima, Shinya Hirata, Hidetake Matsuyoshi, Yasuharu Nishimura. Pluripotent stem cell-derived dendritic cells for immunotherapy. Frontiers in Bioscience-Elite. 2010. 2(4); 1520-1527.