Open Access
PKB/Akt signaling in heart development and disease
Zai Chang1,Qi Xiao1,Qiuting Feng1,Zhongzhou Yang1
MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Centre of Nanjing University, Nanjing, China
DOI: 10.2741/E207 Volume 2 Issue 4, pp.1485-1491
Published: 01 June 2010
(This article belongs to the Special Issue Signaling in cancer and disease)

In mammals, there are three Akt/PKB (protein kinase B) isoforms termed Akt1/PKBalpha, Akt2/PKBbeta, and Akt3/PKBgamma (hereafter referred to as Akt) that are encoded by three distinct genes localized on different chromosomes. Although the three Akt proteins share high homology and display similar domain structures, mouse genetic studies have demonstrated that they play over-lapping but also differential roles in development and physiology. In this review, we summarize recent advances in understanding the roles of Akt signaling in heart development and disease, together with discussion on Akt signaling connection to key signaling pathways in early cardiac specification. The pioneering work on Akt's function in cardiomyocytes performed by Kenneth Walsh's group, was first reported in the new millennium and thus, it is now the right time to look back at some of the discoveries of Akt's role in cardiac biology over the past decade.

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Zai Chang, Qi Xiao, Qiuting Feng, Zhongzhou Yang. PKB/Akt signaling in heart development and disease. Frontiers in Bioscience-Elite. 2010. 2(4); 1485-1491.