Open Access
Article
Role of PUFAs, the precursors of endocannabinoids, in human obesity and type 2 diabetes
Alejandro Dain1,Gaston Repossi1,Undurti N Das1,Aldo Renato Eynard1
1
Facultad de Ciencias Medicas, Instituto de Biologia Celular, Universidad Nacional de Cordoba, Ciudad Universitaria, Barros esquina Gordillo, Cordoba 5000, Argentina
DOI: 10.2741/E203 Volume 2 Issue 4, pp.1432-1447
Published: 01 June 2010
(This article belongs to the Special Issue Advances in metabolic syndrome and diabetes mellitus)
Abstract

Polyunsaturated fatty acids (PUFAs) serve as precursors of the endocannabinoids (ECs) that are bioactive lipids molecules. Recent studies revealed that ECs participate in several physiological and pathological processes including obesity and type 2 diabetes mellitus. Here we review the experimental and clinical aspects of the role of endocannabinoids in obesity and type 2 diabetes mellitus and the modification of the endocannabinoids by exogenously administered PUFAs. Based on these evidences, we propose that the endocannabinoid system (ECS) can be modulated by exogenous manipulation of PUFAs that could help in the prevention and management of human diseases such as obesity, metabolic syndrome and type 2 diabetes mellitus.

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Alejandro Dain, Gaston Repossi, Undurti N Das, Aldo Renato Eynard. Role of PUFAs, the precursors of endocannabinoids, in human obesity and type 2 diabetes. Frontiers in Bioscience-Elite. 2010. 2(4); 1432-1447.