Open Access
Article
Neuroprotections and mechanisms of inhalational anesthetics against brain ischemia
Qiong Yu1,Hailian Wang1,Jun Chen1,Yanqin Gao1,Weimin Liang1
1
Department of Anesthesiology of Huashan Hospital, affiliated with Fudan University, Shanghai, China
DOI: 10.2741/E189 Volume 2 Issue 4, pp.1275-1298
Published: 01 June 2010
Abstract

The new generation of inhalational anesthetics has been widely used for general anesthesia in both clinical and experimental settings because of their safety, reliability and potency. A neuroprotective role has recently been revealed for some of these anesthetics, including the volatile gases isoflurane, sevoflurane, and desflurane, as well as the inert gas xenon. In vivo and in vitro studies have demonstrated that these gases were able to protect brain against ischemic injury, indicated by the decreases in infarct volumes and neuronal apoptosis. In this review, we [Please see table 1] will briefly introduce the properties of these gases, and discuss in detail their effects on brain ischemia, effective treatment regimens, and neuroprotective mechanisms. Perspectives are also discussed on future study and use of inhalational anesthetics.

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Qiong Yu, Hailian Wang, Jun Chen, Yanqin Gao, Weimin Liang. Neuroprotections and mechanisms of inhalational anesthetics against brain ischemia. Frontiers in Bioscience-Elite. 2010. 2(4); 1275-1298.