Open Access
Recent advances in tissue (pro)renin imaging
Agnes Prokai1,Janos Peti-Peterdi1
Hungarian Academy of Sciences, Research Laboratory for Pediatrics and Nephrology, and 1st Dept of Pediatrics, Semmelweis University, Budapest, Hungary
DOI: 10.2741/E182 Volume 2 Issue 4, pp.1227-1233
Published: 01 June 2010
(This article belongs to the Special Issue Handle region peptide and prorenin receptor)

Due to its pivotal role in blood pressure control and renal pathologies there is renewed interest in renin and its precursor prorenin. Also, the newly discovered (pro)renin receptor is a new element of the ever broadening renin-angiotensin system (RAS). The complexity of RAS including the recently recognized collecting duct site of (pro)renin (a term denoting both renin and prorenin) synthesis requires the use of advanced research techniques such as multiphoton fluorescence microscopy. With the help of this technology we have pioneered an imaging approach to directly visualize (pro)renin content, release and tissue activity in the living kidney. The use of this technology is reviewed here and exemplified by the direct visualization of (pro)renin activity in the collecting duct. New pharmacological tools, the renin inhibitor aliskiren and the handle region peptide (decoy peptide) was used to further characterize the intra-renal, collecting duct RAS.

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Agnes Prokai, Janos Peti-Peterdi. Recent advances in tissue (pro)renin imaging. Frontiers in Bioscience-Elite. 2010. 2(4); 1227-1233.