Open Access
Functional characterization of the decoy peptide, [R10P]IFLKRMPSI[19P]
Ahm Nurun Nabi1,Kazal Boron Biswas1,Yoshie Arai1,Mohammad Nasir Uddin1,Tsutomu Nakagawa1,Akio Ebihara1,Atsuhiro Ichihara1,Tadashi Inagami1,Fumiaki Suzuki1
Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
DOI: 10.2741/E180 Volume 2 Issue 4, pp.1211-1217
Published: 01 June 2010
(This article belongs to the Special Issue Handle region peptide and prorenin receptor)

Decoy peptide (R10PIFLKRMPSI19P) showed its beneficial role in ameliorating the end-stage organ damage related disorders. Subsequently, in vivo and in vitro studies have been carried out to verify its effectiveness in several models using different experimental approaches. These studies with decoy peptide including the "handle" sequence have focused on the association of the (pro)renin receptor and prorenin in the pathogenesis of diabetes and hypertension. However, the function of (pro)renin receptor might be more complex than it was anticipated as it is not only distributed intracellularly and appeared on the cell membrane but also found in plasma. The decoy resembling the N-terminal sequence of prorenin has been useful in determining the structure-function relationship of prorenin and (P)RR. Therefore, this review tries to shed light on the use of decoy peptide in elucidating the functional properties of both prorenin and (pro)renin receptor by pointing out recent studies.

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Ahm Nurun Nabi, Kazal Boron Biswas, Yoshie Arai, Mohammad Nasir Uddin, Tsutomu Nakagawa, Akio Ebihara, Atsuhiro Ichihara, Tadashi Inagami, Fumiaki Suzuki. Functional characterization of the decoy peptide, [R10P]IFLKRMPSI[19P]. Frontiers in Bioscience-Elite. 2010. 2(4); 1211-1217.