Open Access
Prorenin/renin and insulin resistance
Kazi Rafiq1,Yukiko Nagai1,Daisuke Nakano1
Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
DOI: 10.2741/E173 Volume 2 Issue 3, pp.1143-1146
Published: 01 June 2010
(This article belongs to the Special Issue Handle region peptide and prorenin receptor)

Recently we showed that fructose feeding in rats induced nonproteolytic activation of prorenin and subsequent angiotensin II production in skeletal muscle. In addition, a pharmacological inhibitor of prorenin/(pro)renin receptor interaction attenuated the development of insulin resistance. However, the inhibitor did not ameliorate the glucose intolerance in transgenic rats overexpressing the human renin gene. This review article summarizes the current knowledge of the effects of the prorenin/(pro)renin receptor system on insulin resistance and its potential as a therapeutic target.

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Kazi Rafiq, Yukiko Nagai, Daisuke Nakano. Prorenin/renin and insulin resistance. Frontiers in Bioscience-Elite. 2010. 2(3); 1143-1146.