Open Access
Gaseous neurotransmitters and their role in anapyrexia
Luiz G S Branco1,Kenia C Bicego1,Evelin C Carnio1,Quentin J Pittman1
Dental School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
DOI: 10.2741/E154 Volume 2 Issue 3, pp.948-960
Published: 01 June 2010
(This article belongs to the Special Issue Frontiers in thermoregulation research)

Mammals keep their body temperature (Tb) relatively constant even under a wide range of ambient temperature variation. However, in some particular situations it may be beneficial to increase or to decrease Tb. For instance, under hypoxic conditions, a regulated drop in Tb (anapyrexia) takes place which has been reported to be crucial for survival in a number of different species. This review highlights major advances in the research about nitric oxide (NO) and carbon monoxide (CO- where data are relatively less abundant), before focusing on the role played by these gaseous neuromediators in thermoregulation, under the conditions of euthermia and anapyrexia. Available data are consistent with the notion that both NO and CO, acting on the CNS, participate in thermoregulation, with NO decreasing Tb and CO increasing it. However further studies are required before definitive conclusions can be made as to their physiological mechanisms of action.

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Luiz G S Branco, Kenia C Bicego, Evelin C Carnio, Quentin J Pittman. Gaseous neurotransmitters and their role in anapyrexia. Frontiers in Bioscience-Elite. 2010. 2(3); 948-960.