Open Access
Clinical biomarkers and management of post thrombotic syndrome
Antonio Biondi1,Giuseppe Strano1,Luca Ruggeri1,Salvatore Vadala1,Alessandro Tropea1,Francesco Basile1
Section of General Surgery and Oncology, Department of General Surgery, University Medical School of Catania, Italy, Ospedale Vittorio Emanuele Via Plebiscito, 628 - 95100 Catania, Italy.
DOI: 10.2741/E137 Volume 2 Issue 2, pp.771-778
Published: 01 January 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)

The post-thrombotic syndrome (PTS) is a long-term complication of deep venous thrombosis (DVT) that is characterized by chronic, persistent pain, swelling and other signs in the affected limb. PTS is common, burdensome and costly. It is likely to increase in prevalence, since despite widespread use of and improvements in the efficacy of thromboprophylaxis, the incidence of DVT has not decreased over time. Preventing ipsilateral recurrence of DVT, by ensuring an adequate duration and intensity of anticoagulation for the initial DVT and by prescribing situational thromboprophylaxis after discontinuation of oral anticoagulants, is likely to reduce the risk of developing PTS. Pending the results of ongoing studies, stockings are recommended in patients with persistent symptoms or swelling after DVT. Future research should focus on standardizing criteria for PTS diagnosis, identification of DVT patients at high risk for PTS, and rigorously evaluating the effectiveness of stockings, thrombolysis, and venoactive drugs in preventing or treating PTS.

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Antonio Biondi, Giuseppe Strano, Luca Ruggeri, Salvatore Vadala, Alessandro Tropea, Francesco Basile. Clinical biomarkers and management of post thrombotic syndrome. Frontiers in Bioscience-Elite. 2010. 2(2); 771-778.