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Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction
Lorena Musino1,Renata Rossi1,Adolfo Partenza1,Giovanna Mureddu1,Angelo Zinellu1,Patrizia Pilo1,Ignazio Maoddi1,Liana Spazzafumo1,Flavia Franconi1,Luca Deiana1,Ciriaco Carru1
1
Department of Biomedical Sciences, Centre of Excellence for Biotechnology Development and Biodiversity Research, University of Sassari, Sassari, Italy
DOI: 10.2741/E114 Volume 2 Issue 2, pp.559-565
Published: 01 January 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)
Abstract

Although the role of environmental factors in the development of acute myocardial infarction (AMI) has been clearly established, the role of genetic factors is still undefined. The aim of this study was to investigate the association between various gene polymorphisms in the haemostatic system and the risk of myocardial infarction in a very genetic restricted area population of Sardinian young adults with AMI. The study case-control involved 71 patients who had survived a first MI at a mean age of 47,2 years and 150 healthy subjects. No differences in the allele or genotype frequencies were seen between the study groups for the fibrinogen, prothrombin, factor V, factor VII, vWF, TM, PAI-1, TPO gene, and PLA and HPA-2 genes polymorphisms. Indeed differences statistically significant were detected for A5709G in the TPO gene (P= 0,041), and I/D dimorphism in the eNOS gene (P= 0,016). We therefore conclude that among all the investigated polymorphisms only the 5709G and eNOS4a alleles seem to confer protection against MI in the young age of Sardinian people.

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Lorena Musino, Renata Rossi, Adolfo Partenza, Giovanna Mureddu, Angelo Zinellu, Patrizia Pilo, Ignazio Maoddi, Liana Spazzafumo, Flavia Franconi, Luca Deiana, Ciriaco Carru. Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction. Frontiers in Bioscience-Elite. 2010. 2(2); 559-565.