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Dendritic cell immunobiology in relation to liver transplant outcome
Tina L Sumpter1,John G Lunz 3rd1,Antonino Castellaneta1,Benjamin Matta1,Daisuke Tokita1,Heth R Turnquist1,George V Mazariegos1,A Jake Demetris1,Angus W Thomson1
1
Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, BST W1540, Pittsburgh, PA 15261, USA
DOI: 10.2741/E11 Volume 1 Issue 1, pp.99-114
Published: 01 June 2009
(This article belongs to the Special Issue Innate immune mechanisms in organ transplantation)
Abstract

The unique immunologic environment of the liver, together with its anatomic location downstream of the gut, influences the maturation and function of its interstitial dendritic cell (DC) populations. These well-equipped, antigen-presenting cells play critical roles in regulation of innate and adaptive immunity. New information is emerging about the molecular regulation of liver DC maturation and function, and their tolerogenic potential, while new insight is being gained regarding interactions between liver DC and other immune effector cell populations (NK, NKT cells) in addition to T cells. During transplantation, factors that affect liver DC biology include ischemia-reperfusion injury, liver regeneration, viral infection and the actions of anti-inflammatory and immunosuppressive drugs. Herein, we review the molecular and cell biology of hepatic DC populations in relation to the regulation of alloimmune responses and liver transplant outcome.

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Tina L Sumpter, John G Lunz 3rd, Antonino Castellaneta, Benjamin Matta, Daisuke Tokita, Heth R Turnquist, George V Mazariegos, A Jake Demetris, Angus W Thomson. Dendritic cell immunobiology in relation to liver transplant outcome. Frontiers in Bioscience-Elite. 2009. 1(1); 99-114.